Protein Molecular Weight Markers
ABclonal Technology TRIM24 Rabbit pAb
The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
ABclonal Technology BMP10 Rabbit pAb
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which binds to the activin receptor-like kinase 1 (ALK1) and plays important roles in cardiovascular development including cardiomyocyte proliferation and regulation of heart size, closure of the ductus arteriosus, angiogenesis and ventricular trabeculation.
ABclonal Technology MGAT4A Rabbit pAb
This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme B, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation.
ABclonal Technology NAIF1 Rabbit pAb
Involved in negative regulation of cell growth and regulation of mitochondrial membrane permeability involved in apoptotic process. Located in cytosol, nucleoplasm, and plasma membrane.
ABclonal Technology TAF1 Rabbit pAb
This gene encodes the largest subunit of TFIID, a basal transcription factor required for RNA polymerase II activity. TFIID binds to the core promoter to position the polymerase and assembles the transcription complex. It also serves as a channel for regulatory signals and interacts with activators and other regulators to influence transcription initiation. This subunit contains two protein kinase domains and has acetyltransferase activity, acting as a ubiquitin-activating/conjugating enzyme. Mutations in this gene cause Dystonia 3, torsion, X-linked, a dystonia-parkinsonism disorder. Alternative splicing results in multiple transcript variants, some sharing exons with TAF1 and additional downstream DYT3 exons.
ABclonal Technology Bmi1 Rabbit pAb
This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene.
ABclonal Technology NDUFAB1 Rabbit pAb
Predicted to enable acyl binding activity, acyl carrier activity, and fatty acid binding activity. Involved in mitochondrial respiratory chain complex I assembly and protein lipoylation. Located in mitochondrion and nucleoplasm. Part of mitochondrial respiratory chain complex I. Colocalizes with mitochondrial large ribosomal subunit.
ABclonal Technology CTNNA2 Rabbit pAb
Enables actin filament binding activity. Involved in negative regulation of Arp2/3 complex-mediated actin nucleation, regulation of neuron migration, and regulation of neuron projection development. Located in cytoplasm. Implicated in complex cortical dysplasia with other brain malformations.
S2 Media 15x100mm Chameleon™ COLOREX Salmonella, 10/pack
Chameleon™ COLOREX Salmonella is a selective and differential, chromogenic culture medium used for the qualitative direct detection and presumptive identification of Salmonella. Test specimens include rectal swabs and stools. Concomitant cultures should be performed to recover organisms for further microbiological testing or epidemiological typing. Further identification, susceptibility testing, and epidemiological typing should be performed on suspect colonies. • Product meets CLSI performance criteria.• Chameleon™ COLOREX™ Salmonella should be used by trained professionals within a laboratory setting. • For in vitro diagnostic (IVD) use.• Product is not intended for use in the diagnosis or treatment of disease or other human conditions.
ABclonal Technology COQ9 Rabbit pAb
This locus represents a mitochondrial ubiquinone biosynthesis gene. The encoded protein is likely necessary for biosynthesis of coenzyme Q10, as mutations at this locus have been associated with autosomal-recessive neonatal-onset primary coenzyme Q10 deficiency.
ABclonal Technology APH1A Rabbit pAb
This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimers disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants.
ABclonal Technology GAS7 Rabbit pAb
Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary in the N-terminus have been described.
ABclonal Technology DDAH1 Rabbit pAb
This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity.
ABclonal Technology TERF1 Rabbit pAb
This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Multiple transcripts of this gene are alternatively spliced products.
Biolegend Prime-Step™ Prestained Broad Range Protein Ladder
Prime-Step™ Prestained Broad Range Protein Ladder Apps: WB; Size: 50 uL